The use of topical drug delivery methods is appealing because they offer easy administration, bypass the initial metabolic process, and utilize the extensive skin surface area. Drug molecules can penetrate the skin surface via two pathways: transcellular and intercellular. Permeation enhancers temporarily increase skin permeability, facilitating drug absorption. This article explores various classifications of permeation enhancers, including physical, chemical, and natural agents.

Pratik Barve* & Neha Patil

SC- Stratum corneum, TDDS- Transdermal drug delivery system, OTC- Over the counter, DMF- dimethyl formamide, DMAC- dimethyl acetamide