The objective of the research work was to develop an effective formulation for enteric-coated pellets of lansoprazole. The active ingredients and fillers in bulk pharmaceuticals were compressed into pellets. They are typically intended for oral delivery and have a unit size ranging from around 0.5mm to 1.5mm with a spherical or semi-spherical shape. There are a variety of ways to make pellets, but the most common include compression and drug stacking. The purpose of this research was to create a delayed-release pellet dosage form of lansoprazole, a Benz-imidazole anti-ulcer agent that is one of the most commonly prescribed medications for both mild and severe ulcers. In this investigation, polymers such as Hypromellose and Eudragit L30 D55 were used to create enteric-coated pellets. Suspension layering was used to create the pellets. USP II equipment was used to examine the release of the drug from the enteric-coated pellets in 0.1 N HCL and phosphate buffer at pH 6.8. The cumulative percentage of drug release was calculated.

Ayre Anita*, Karia Palak

Pellets, Lansoprazole, suspension layering method, Hypromellose, Eudragit L30 D55