Lipid based drug delivery systems provide an effective way to deliver drugs with different molecular weights (small and large Molecular weight) and bioactive ingredients at specific locations and times. Poorly water-soluble drugs present a challenge to formulation scientists in terms of solubility and bioavailability. Simple oil solutions and complicated blends of oils, co-surfactants, surfactants, and cosolvents are both examples of lipid-based delivery systems. Nevertheless, lipid excipients have the ability to solubilize hydrophobic drugs in the matrix of the dosage form. A decrease in the barriers of poor aqueous solubility and a slow drug dissolution rate in the gastrointestinal (GI) fluids leads to enhanced drug absorption, which is predominantly mediated by these factors. The quantity of potential excipients available to the formulator to select from when creating lipid-based formulations can appear daunting. Several currently available kinds of lipid excipients will be discussed in this review article regarding their pharmaceutically useful properties: Natural oils, fatty acids, and fatty acids Semi-synthetic mono-, di-, and triglycerides, as well as derivatives of glycerides, fatty acids, and cholesterol, as well as Polyglyceryl and phospholipids, as well as Polyglyceryl fatty acid esters.

Syed Abdul Zahed, Pawar Yash, Kalambkar Rajan*

Lipid-based drug delivery systems, controlled delivery, Lipid Excipients