Despite available data and research on impurities of Amlodipine there is a scope for further development of analytical method for identification of crucial impurities in the available samples. This paper undertakes the identification of crucial impurities Impurity G and impurity 6 in amlodipine as API using in silico method of ADMET prediction. The identified impurities were synthesized using simple, organic chemistry method and were characterized using IR, NMR and Mass spectroscopy. Subsequently a reverse phase HPLC based method was developed and validated for identification and quantification of these impurities.

Sandhya Mishra, Anita Ayre, Mushtaque. A. S. Shaikh

Amlodipine; Impurity G; Impurity 6; ADMET Prediction; RP-HPLC.