Polycystic Ovarian Syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, characterized by hormonal imbalances, insulin resistance, and ovarian dysfunction. Despite its high prevalence, current treatment options for PCOS are limited and often focus on symptom management rather than addressing the underlying causes. This study aims to explore the therapeutic potential of Guava (Psidium guajava L.) leaf, a medicinal plant known for its anti-inflammatory and antioxidant properties, through network analysis to identify potential drug repurposing opportunities for PCOS treatment. Using a network pharmacology approach, bioactive compounds present in Guava leaf were identified and their interactions with key proteins involved in PCOS were mapped. The network analysis revealed several critical pathways and gene targets that are modulated by Guava leaf compounds, particularly those associated with insulin resistance, androgen production, and inflammation—central factors in the pathophysiology of PCOS. Additionally, the study highlighted the potential for repurposing existing drugs that target similar pathways, thereby offering new therapeutic strategies for PCOS management. Docking studies were carried out to predict the molecular mechanism between the target and actives. The findings suggest that Guava leaf could be a promising candidate for further investigation as a natural adjunct therapy in PCOS treatment, potentially improving outcomes for patients through a multi-targeted approach. This research underscores the importance of integrating traditional medicinal knowledge with modern computational tools to uncover novel applications of natural products in the treatment of complex diseases like PCOS.

Dr. Shweta A. More, Dr. Mushtaque Shaikh

Psidium guajava L., network analysis, PCOS